Preclinical Antiviral and Safety Profiling of the HBV RNA Destabilizer AB-161
HBV RNA destabilizers are a class of small-molecule compounds that target the noncanonical poly(A) RNA polymerases PAPD5 and PAPD7, resulting in HBV RNA degradation and the suppression of viral proteins including the hepatitis B surface antigen (HBsAg).AB-161 is a next-generation HBV RNA destabilizer with potent antiviral activity, inhibiting HBsAg